Download e-book for iPad: Applications of Biotechnology in Neurology by Kewal K. Jain

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By Kewal K. Jain

ISBN-10: 1627032711

ISBN-13: 9781627032711

ISBN-10: 162703272X

ISBN-13: 9781627032728

Culling jointly excerpts from a variety of writings by way of Dr. Kewal okay. Jain on biotechnology subject matters as they relate to issues of the anxious method, Applications of Biotechnology in Neurology covers numerous purposes for these operating in existence sciences and the pharmaceutical sciences, quite these constructing diagnostics and therapeutics for the apprehensive method. This certain quantity delves into parts resembling neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, a variety of equipment of enhancing systemic management of gear for special supply to the fearful process, together with using nanobiotechnology, biotechnology-based suggestions and items for neuroprotection, in addition to chapters on neurosurgery and custom-made neurology.

Thorough, state of the art, and thoughtfully geared up, Applications of Biotechnology in Neurology serves as a fantastic consultant, supplemented by means of seventy five tables and sixteen figures in addition to a number of references from fresh literature in this subject, that are appended to every chapter.

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These are created cloning DNA from chromosomes separated on the basis of size. cDNA libraries. A DNA library is the mixture of cDNAs from a given tissue. Techniques are available to insert cDNA into specialized DNA loops called vectors, which can reproduce inside bacterial cells. Such cDNA libraries are often preferable to genomic libraries as a source of cloned genes for the following reasons: • The clone represents the coding sequence. These libraries are constructed by cloning only the end points of large genomic fragments.

2007). Several technological advances enable the analysis of thousands of expressed genes in a small brain sample. These techniques include expressed sequence tags, sequencing of cDNA libraries, differential display, subtractive hybridization, serial analysis of gene expression; and the high density DNA microarrays. Gene expression measurements may be used to identify genes that are abnormally regulated as a secondary consequence of a disease state, or to identify the response of brain cells to pharmacological treatments.

This method has been used to identify genes that are involved in Huntington disease. Neurogenomics 11 Detection of Gene Mutations The final challenge in gene identification is to determine which one of the candidate genes is mutated in a patient with a certain disease. Several types of mutations responsible for inherited disorders have been identified by this approach. Biochip technology is now being applied for detection of genetic mutations. Biochips/Microarrays Biochips/microarrays technology (also known as gene chip or “biochip”) are rapid methods of sequencing and analyzing genes.

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Applications of Biotechnology in Neurology by Kewal K. Jain

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