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By R. J. Roberts

ISBN-10: 0203484509

ISBN-13: 9780203484500

ISBN-10: 0748408150

ISBN-13: 9780748408153

Apoptosis in Toxicology is the 1st e-book to target the molecular law of apoptosis with specific emphasis on toxicant motion. telephone survival signalling and its perturbation is addressed on the genetic and biochemical point, together with key survival and dying genes, survival signalling, dedication to apoptosis and recruitment of the initiator and executioner caspases. Emphasis is given to the position apoptosis performs within the motion of toxicants within the mind, the immune method, the reproductive organs, the kidney and the liver. the facility of gear to control apoptosis both as a goal or as an antagonistic impression is mentioned with specific connection with melanoma chemotherapy. the numerous tools that may be hired to quantify apoptosis are in comparison and their software to diverse tissues is mentioned. This well timed and complete quantity has been written by way of prime experts and lively researchers of their respective fields. it is going to have huge entice toxicologists, physicians and biologists throughout many disciplines.

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FERNANDESALNEMRI, T. W. S. , 1998, Anti-apoptotic oncogenes prevent caspase dependent and independent commitment for cell death, Cell Death and Differentiation, 5, 298–306 ASHKENAZI, A. D. , 1998, Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarisation. , WANG, J. A. M. , DIXIT, V. H. J. S. , 1997, X-linked IAP is a direct inhibitor of cell-death proteases, Nature, 388, 300–303 36 ! TOXICOLOGICAL CONSEQUENCES OF CASPASE INHIBITION DUAN, H.

Apaf-1 is the first identified mammalian homologue of CED-4. It is a large (Mr=130 kDa) soluble protein with a short N-terminal CARD domain, a central CED-4 homology domain followed by twelve WD-40 repeats, which are probably involved in protein-protein interactions. 3). The activated caspase then processes caspase3 and initiates the caspase cascade. , 1996) which can be cleaved by caspase-3, it is possible that activation of caspase-3 leads to further cleavage of caspase-9, thereby amplifying the caspase activation event.

A. M. , DIXIT, V. H. J. S. , 1997, X-linked IAP is a direct inhibitor of cell-death proteases, Nature, 388, 300–303 36 ! TOXICOLOGICAL CONSEQUENCES OF CASPASE INHIBITION DUAN, H. W. , 1996, Ice-lap6 a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B, Journal of Biological Chemistry, 271, 16720–16724 EVAN, G. M. W. R. M. C. H. , MACKENZIE, A. , RAKIC, P. , 1995, Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme.

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Apoptosis in Toxicology by R. J. Roberts

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