Antibiotic Optimization:Concepts and Strategies in Clinical by Jr., Robert C. Owens, Charles H. Nightingale, Paul G. PDF
By Jr., Robert C. Owens, Charles H. Nightingale, Paul G. Ambrose
This ebook makes a speciality of subject matters starting from the economics of drug-resistant infections and the administration of antimicrobial use to new info on the right way to optimize the choice, course of management, dosing, and period of antimicrobial treatments for universal infections. as well as delivering rules on studied programmatic methods for sensible usage of antimicrobial brokers, this reference discusses sensible skill to trace intervention results via benchmarking. Authored by way of specialists of their respective fields, the e-book includes crucial ideas and sensible techniques to optimize the software of antimicrobial brokers in sleek inpatient future health care settings.
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Extra info for Antibiotic Optimization:Concepts and Strategies in Clinical Practice (HBK) (Infectious Disease and Therapy)
Given the current trend of greater severity of illness for critically ill patients, it can be expected that infections due to antibiotic-resistant bacterial strains will be associated with greater morbidity and mortality, particularly when inappropriate empiric antimicrobial therapy is administered (12). Along with greater patient mortality rates, antibiotic-resistant bacterial infections and inappropriate antimicrobial treatment are associated with prolonged hospitalization and increased health care costs relative to antibioticsensitive bacterial infections (15,27,28).
For example, information on the initial drug regimen prescribed coupled with information on initial drug susceptibility results allows a judgment about the adequacy of therapy and corrective action on individual cases by public health officials and health care providers if the regimen is judged to be inadequate or suboptimal. For most other infections in most communities, a similar system that provides patient specific data is not needed to help develop and evaluate national prevention and control strategies.
Use of the guideline was associated with a statistically significant increase in the administration of appropriate antimicrobial treatment, a decrease in the development of secondary episodes of antibioticresistant VAP, and a reduction in the total duration of antimicrobial treatment. The studies of Trouillet et al. and Ibrahim et al. employed local bacterial susceptibility data in order to develop recommendations for empiric therapy within their respective ICUs. The use of local data should always be taken into consideration when developing empiric regimens for treatment.
Antibiotic Optimization:Concepts and Strategies in Clinical Practice (HBK) (Infectious Disease and Therapy) by Jr., Robert C. Owens, Charles H. Nightingale, Paul G. Ambrose