Clinical

Download PDF by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D.: Angiotensin II Receptor Blockade Physiological and Clinical

Posted On February 7, 2018 at 9:19 pm by / Comments Off on Download PDF by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D.: Angiotensin II Receptor Blockade Physiological and Clinical

By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)

ISBN-10: 1461376319

ISBN-13: 9781461376316

ISBN-10: 1461557437

ISBN-13: 9781461557432

The courting among angiotensin II and high blood pressure was once tested in 1898 whilst angiotensin II was once proven to modulate systemic blood strain. Over the intervening many years, a whole characterization of the renin-angiotensin method (RAS) has been accomplished, and our realizing of its biochemistry and body structure has ended in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists able to controlling high blood pressure. extra lately, it was once proven that angiotensin II is secreted inside convinced tissues and that those tissue-specific platforms function independently of the systemic RAS. the radical idea that angiotensin II regulates a few cardiovascular methods which are unrelated to blood strain has renewed the curiosity of either uncomplicated and medical scientists in angiotensin II. The organization among angiotensin II and cardiac progress, specifically, has indicated that remedies at present in use for high blood pressure could have direct software to the remedy of center failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg used to be convened October 18-20, 1996 to envision the medical and easy elements of angiotensin receptor biology as they practice to high blood pressure and middle failure. furthermore, the capability remedy of those stipulations utilizing particular angio­ tensin receptor antagonists was once addressed in the context in their speedy healing software and destiny potential.

Show description

Read or Download Angiotensin II Receptor Blockade Physiological and Clinical Implications PDF

Similar clinical books

Download e-book for kindle: Clinical Cardiac Electrophysiology: Techniques and by Mark E. Josephson

Absolutely revised and up to date for its Fourth version, Dr. Josephson's vintage textual content presents an intensive figuring out of the mechanisms of cardiac arrhythmias and the healing interventions used to regard arrhythmias. The publication information the electrophysiologic technique required to outline the mechanism and placement of foundation of arrhythmias in order that secure and powerful treatment may be selected.

Download PDF by Patricia Benner, Patricia Kyriakids & Daphne Stannard: Clinical Wisdom and Interventions in Acute and Critical

[This e-book is] a lavishly exact consultant to the essence of changing into a professional nurse. .. i feel this e-book will safe a spot on such a lot educators' and specialist clinicians' bookshelves. each on occasion a greater booklet comes alongside; this is often a kind of occasions. From the foreword by means of Joan E. Lynaugh, PhD, RN, FAAN Professor Emeritus, college of Pennsylvania university of Nursing A vintage research-based textual content in nursing perform and schooling, this newly revised moment variation explains, via first-hand debts of the well-merited experiential knowledge of professional nurses, the medical reasoning abilities priceless for top-tier nursing in acute and important settings.

Download e-book for kindle: Nutrition: Metabolic and Clinical Applications by John Lindenbaum (auth.), Robert E. Hodges (eds.)

The technological know-how of food has complicated past expectation considering that Antoine los angeles­ voisier as early because the 18th century confirmed that oxygen used to be essential to switch nutrition in meals to compounds which might develop into part of the human physique. He was once additionally the 1st to degree metabolism and to teach that oxidation in the physique produces warmth and effort.

Get Urolithiasis: Clinical and Basic Research PDF

In 1968 Drs. B. E. C. Nordin and A. Hodgkinson equipped the 1st foreign Symposium on Urolithiasis study in Leeds, England. one zero five contributors from continental Europe, nice Britain, and the U.S. met to study their paintings and alternate rules concerning the formation of urinary calculi.

Extra resources for Angiotensin II Receptor Blockade Physiological and Clinical Implications

Sample text

Should that be the case, alternatives for blocking the renin system via renin inhibition or competitive Ang II antagonists would have limited therapeutic application. Another view is possible. No phannacologist examining the renin cascade would have chosen to block the ACE step. The first step-the renin: angiotensinogen interaction-is rate limiting, and remarkably specific, which would have made it a much more attractive alternative. The Ang II receptor provides a second attractive target [7]. Because Ang II fonnation can be catalyzed by a number of serine poteases, which are ubiquitous, phannacological interruption at the Ang II receptor level has the distinct potential advantage of blocking the action of Ang II, whatever the pathway of its fonnation.

Dzau YJ, Colucci WS, Williams GH, Curfman G, Meggs L, Hollenberg NK. 1980. Sustained effectiveness of converting enzyme inhibition in patients with severe congestive heart failure. N Eng! J Med 302:1373-1379. Renin System Interruption 13 34. Creager MA, Halperin JL, Bernard DB, Faxon DP, Melidossian CD, Gavras H, Ryan 'I). 1981. Acute regional circulatory and renal hemodynamic effects of converting-enzyme inhibition in patients with congestive heart fiUlure. Circulation 64:483-489. 35. The CONSENSUS Trial Study Group.

Lafayette RA, Mayer G, Park SK, Meyer TW. 1992. Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest 90:766-771. 45. Gansevoort RT, de Zeeuw D, de Jong PE. 1994. Is the antiproteinuric effect of ACE inhibition mediated by interference in the renin-angiotensin system? Kidney International 45:861-867. 46. Ichikawa I. 1996. Will Ang II Al be renoprotective in humans? Kidney Intern 50:684-692. 47. Roman RJ, Kaidunski ML, Scicli AG, Carretero DA. 1988.

Download PDF sample

Angiotensin II Receptor Blockade Physiological and Clinical Implications by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)


by Kenneth
4.3

Rated 4.23 of 5 – based on 22 votes