Download PDF by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D.: Angiotensin II Receptor Blockade Physiological and Clinical
By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)
The courting among angiotensin II and high blood pressure was once tested in 1898 whilst angiotensin II was once proven to modulate systemic blood strain. Over the intervening many years, a whole characterization of the renin-angiotensin method (RAS) has been accomplished, and our realizing of its biochemistry and body structure has ended in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists able to controlling high blood pressure. extra lately, it was once proven that angiotensin II is secreted inside convinced tissues and that those tissue-specific platforms function independently of the systemic RAS. the radical idea that angiotensin II regulates a few cardiovascular methods which are unrelated to blood strain has renewed the curiosity of either uncomplicated and medical scientists in angiotensin II. The organization among angiotensin II and cardiac progress, specifically, has indicated that remedies at present in use for high blood pressure could have direct software to the remedy of center failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg used to be convened October 18-20, 1996 to envision the medical and easy elements of angiotensin receptor biology as they practice to high blood pressure and middle failure. furthermore, the capability remedy of those stipulations utilizing particular angio tensin receptor antagonists was once addressed in the context in their speedy healing software and destiny potential.
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Extra resources for Angiotensin II Receptor Blockade Physiological and Clinical Implications
Should that be the case, alternatives for blocking the renin system via renin inhibition or competitive Ang II antagonists would have limited therapeutic application. Another view is possible. No phannacologist examining the renin cascade would have chosen to block the ACE step. The first step-the renin: angiotensinogen interaction-is rate limiting, and remarkably specific, which would have made it a much more attractive alternative. The Ang II receptor provides a second attractive target . Because Ang II fonnation can be catalyzed by a number of serine poteases, which are ubiquitous, phannacological interruption at the Ang II receptor level has the distinct potential advantage of blocking the action of Ang II, whatever the pathway of its fonnation.
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Lafayette RA, Mayer G, Park SK, Meyer TW. 1992. Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest 90:766-771. 45. Gansevoort RT, de Zeeuw D, de Jong PE. 1994. Is the antiproteinuric effect of ACE inhibition mediated by interference in the renin-angiotensin system? Kidney International 45:861-867. 46. Ichikawa I. 1996. Will Ang II Al be renoprotective in humans? Kidney Intern 50:684-692. 47. Roman RJ, Kaidunski ML, Scicli AG, Carretero DA. 1988.
Angiotensin II Receptor Blockade Physiological and Clinical Implications by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)