Philip C. Burcham (auth.)'s An Introduction to Toxicology PDF
By Philip C. Burcham (auth.)
This publication presents a readable creation to fashionable toxicology with a selected concentrate on the mechanisms underlying the induction of toxicity through international ingredients. in view that bioactivation is vital to many poisonous syndromes, particular curiosity is dedicated to chemical compounds that endure conversion to poisonous metabolites that set off poisonous results as various as melanoma, beginning defects and organ harm. The molecular outcomes accompanying harm to mobile DNA and proteins is explored including the relevance of toxicological paradigms to human illnesses as a result of alcohol and tobacco. The self-discipline of toxicology has constructed speedily because the thalidomide catastrophe within the 1960’s as scientists all over the world search to appreciate the opposed wellbeing and fitness results of human drugs, environmental pollution, purchaser chemical substances and commercial reagents. An creation to Toxicology is meant to complement the advised examining record of undergraduate and graduate courses in toxicology and pharmacology as an relaxing, available primer with illustrations that “unpack” the recommendations being mentioned within the textual content.
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Extra resources for An Introduction to Toxicology
Although Dr McBride’s reputation would be tarnished through his later involvement in a controversial case involving another drug – Debendox – he 16 1 The Emergence of Modern Toxicology deserves credit for being the first to implicate thalidomide in the plague of birth defects that was then breaking out all over the world. Meanwhile in Germany, the epicentre of the evolving disaster, another vigilant clinician – Dr Widukind Lenz – was suspicious that thalidomide was causing the outbreak of severe limb malformations among babies born in his country.
G. androgens, glucocorticoids, neurotransmitters, eicosanoids and metabolic waste products such as bilirubin). Endobiotics also include toxic chemicals that form within diseased tissues via pathological processes. In theory, xenobiotic excludes these endogenous substances and instead denotes the tens of thousands of synthetic chemicals in widespread use in today’s world, including food additives, industrial pollutants, consumer products, medicines, recreational drugs, pesticides, herbicides and industrial reagents.
In: Hayes AW, editor. Principles and methods of toxicology. 4th ed. Philadelphia: Taylor & Francis; 2001. p. 1–21. Earles MP. Early theories on the mode of action of drugs and poisons. Ann Sci. 1961;17:97–110. Emsley J. The elements of murder: a history of poison. Oxford: Oxford University Press; 2005. Langman LJ, Kapur BM. Toxicology: then and now. Clin Biochem. 2006;39:498–510. Orfila M. A general system of toxicology. (This abridged English translation of Orfila’s 2-volume text was published M.
An Introduction to Toxicology by Philip C. Burcham (auth.)