Feigal, Ellen G.'s AIDS-Related Cancers and Their Treatment PDF

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By Feigal, Ellen G.

ISBN-10: 0824746805

ISBN-13: 9780824746803

ISBN-10: 0824776690

ISBN-13: 9780824776695

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Haematologica 74:605–622, 1989.  Cancer after bone marrow transplantation. Bone Marrow Transplant 10(supp 1):135–138, 1992.  RE Curtis, PA Rowlings, HJ Deeg, DA Shriner, G Socié, LB Travis, MM Horowitz, RP Witherspoon, RN Hoover, KA Sobocinski, JF Fraumeni, JD Boice.  N Engl J Med 336:897–904, 1997.  J Pediatr Surg 29:221–228, 1994.  Cancer Res 52:5477s–5478s, 1992.  Lancet 1:583–587, 1984.  Br J Dermatol 118:709–714, 1987.  67: Human Immunodeficiency Viruses and Human T­Cell Lymphotropic Viruses.

Because KS can occur earlier than other AIDS­related illnesses in the course of HIV­related immune deterioration, the average CD4 counts are higher than are seen in many other AIDS illnesses.  Thus far, this has been observed only occasionally in AIDS patients.  However, these cases may also indicate the presence of causal factors, in addition to HIV, to which homosexual men may be exposed by their lifestyle.  The findings have been difficult to interpret because they usually involve multiple associations that are, in turn, related to each other.

Of interest, NHL risk in patients with renal transplants is associated with cadaveric (rather than sibling) kidneys, and with having multiple transplants, raising the possibility that antigenic stimulation could be related to the etiology (65).  These observations strongly suggest that immune function may affect tumor expression, even after the emergence of the tumor.  Finding excesses of KS and NHL, therefore was, consistent with the other laboratory and clinical evidence of immunodeficiency in AIDS.

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AIDS-Related Cancers and Their Treatment by Feigal, Ellen G.

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