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Get Advances in Hematopoietic Stem Cell Transplantation and PDF

Posted On February 7, 2018 at 10:55 pm by / Comments Off on Get Advances in Hematopoietic Stem Cell Transplantation and PDF

By Priv.-Doz. Dr. med. Rainer Haas, Dr. med. Ralf Kronenwett, Priv.-Doz. Dr. rer. nat. Georg Sczakiel (auth.)

ISBN-10: 3642468365

ISBN-13: 9783642468360

ISBN-10: 3642468381

ISBN-13: 9783642468384

This ebook provides an outline of the present state-of-the-art in peripheral blood stem telephone transplantation and up to date advancements in molecular analysis and gene healing ways. the focal point is at the function of peripheral blood stem phone transplantation within the remedy of hematological malignancies equivalent to non-Hodgkin lymphomas, persistent myelogenous leukemia and a number of myeloma. present molecular organic suggestions for detecting genetic defects in tumors and minimum residual illness also are offered. additional themes contain new gene healing innovations in hematology and oncology: using viral vectors for transduction of hematopoietic cells is mentioned in addition to healing techniques in response to antisense nucleic acids, ribozymes, and immunological approaches.

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Extra resources for Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy

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11 Overall survival ::u II!! 4 .!!! 0 0 5 10 15 20 25 30 35 40 4S 50 Survival Time in Months Fig. 2. Overall and event·free survival after PBPCT in 104 patients with multiple myeloma ysis of the French multicenter trial IFM 90 showed a significantly longer event-free and overall survival following high-dose treatment (Attal et al. 1996). Similar results were presented in 1995 by Barlogie et al. at the ASH meeting. The data from the Royal Marsden group (Cunningham et al. 1994) show that high-dose melphalan is the most active agent in the treatment of multiple myeloma.

J Clin OncoI7:1018-1026 Coleman CN, Picozzi VJ, Cox RS et al (1986) Treatment of lymphoblastic lymphoma in adults. J Clin Oncol 4:399-404 Fisher RI, Gaynor E, Dahlberg S et al (1993) Comparison of a standard regimen (CHOP) with three intensive chemotherapy regiments for advanced non-Hodgkin's lymphoma. N Engl J Med 328:1002-1006 Gianni AM (1994) 5-Year update of the Milan Cancer Institute randomized trial of highdose sequential (HDS) vs MACOP-B therapy for diffuse large-cell lymphomas. Proc Am Soc Clin Oncol 13:373 Gisselbrecht C, Lepage E, Fermand JP et al (1984) Intensive induction treatment in nonHodgkin lymphomas with various grades of malignancy.

1993; Hochhaus et al. 1996b). In order to standardize results for both quality and quantity of blood, RNA, and cDNA, quantification of transcripts of the normal ABL gene is used; the standardized result is expressed as the ratio BCR-ABLlABL in percent. Quantification of the transcript level of normal genes is of particular importance if different RNA qualities are expected, especially if samples from multicenter trials are mailed to a reference laboratory. Following up patients after allogeneic BMT, out of 69 patients with low or falling BCR-ABL transcripts 3% relapsed, compared to 79% relapses in 29 patients with high or rising BCR-ABL transcript levels.

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Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy by Priv.-Doz. Dr. med. Rainer Haas, Dr. med. Ralf Kronenwett, Priv.-Doz. Dr. rer. nat. Georg Sczakiel (auth.)


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