Download e-book for iPad: ABC of Clinical Haematology, 3rd Edition (ABC Series) by Drew Provan
By Drew Provan
This ABC has demonstrated itself as a well-liked advent to medical Haematology, appropriate either for postgraduate scholars and first care practitioners. Now in its 3rd variation, the ABC of medical Haematology has been completely revised, that includes the newest remedies for leukemia, antithrombotics and medication for lymphoma and protecting the most recent advances in hematology and bone marrow transplantation. With every one bankruptcy written by means of experts of their respective fields, this is often a fantastic uncomplicated textual content for common perform and sanatorium employees with sufferers who've blood comparable difficulties, specifically GPs, hematology nurses, junior medical professionals, hematologists, and trainees in hematology.
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Extra info for ABC of Clinical Haematology, 3rd Edition (ABC Series)
The Ph chromosome carries a specific fusion gene known as bcr– abl, which results from juxtaposition of part of the abl proto-oncogene (from chromosome 9) with part of the bcr gene on chromosome 22. This fusion gene is expressed as a specific messenger (m) RNA, which in turn generates a protein called p210Bcr–Abl. This protein perturbs stem cell kinetics and associated myelopoiesis, resulting in the chronic phase of CML, although the exact mechanism remains unclear. 1 Formation of the Philadelphia chromosome resulting in a bcr–abl fusion gene that generates a fusion protein (p210) responsible for the chronic myeloid leukaemia (CML) phenotype.
The condition can be cured with bone marrow transplantation (BMT). Thrombocytopenia with absent radii Thrombocytopenia with absent radii (TAR) syndrome presents with the pathognomonic sign of bilateral absent radii (Fig. 2) and with severe (< 10 × 109/L) neonatal thrombocytopenia, although this often improves after the first year of life. This should be distinguished from amegakaryocytic thrombocytopenia, another leukaemia predisposition syndrome, in which severe neonatal thrombocytopenia is present with orthopaedic or neurological abnormalities in 10–30% of children.
The Ph chromosome is derived from a normal 22 chromosome that has lost part of its long arm as a result of a balanced reciprocal translocation of chromosomal material involving one of each pair of chromosomes 9 and 22; thus the translocation is t(9;22)(q34;q11). The Ph chromosome (also known as 22q–) therefore appears somewhat shorter than its normal counterpart, and the 9q+ somewhat longer than the normal chromosome 9. The Ph chromosome carries a specific fusion gene known as bcr– abl, which results from juxtaposition of part of the abl proto-oncogene (from chromosome 9) with part of the bcr gene on chromosome 22.
ABC of Clinical Haematology, 3rd Edition (ABC Series) by Drew Provan