Toxicology

Download PDF by David Woolley, Visit Amazon's Adam Woolley Page, search: A Guide to Practical Toxicology: Evaluation, Prediction, and

Posted On February 7, 2018 at 7:08 pm by / Comments Off on Download PDF by David Woolley, Visit Amazon's Adam Woolley Page, search: A Guide to Practical Toxicology: Evaluation, Prediction, and

By David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

ISBN-10: 1420043145

ISBN-13: 9781420043143

This useful, easy, and informative textual content surveys easy ideas of toxicology. it really is a useful consultant to comparing toxicity and similar info, impending toxicity trying out and interpretation, and knowing the thoughts of threat prediction and danger review and management.

A advisor to sensible Toxicology:

  • examines tips to overview quite a few teams of chemicals—pharmaceuticals, cosmetics, and agrochemicals
  • provides insights on toxicity decision, normality and naturality, prediction, and regulation

Two all-new chapters cover:

  • safety pharmacology
  • evaluation of alternative chemical classes
  • Show description

Read or Download A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition PDF

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Additional info for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition

Sample text

The most common factor is variation or deficiency in metabolic enzyme activity. Early discoveries of this were made with isoniazid and debrisoquine, both of which were associated with genetic polymorphisms—slower acetylation of isoniazid and deficient hydroxylation of debrisoquine. There is great variation in paracetamol (acetaminophen) metabolism among individuals by a factor of up to ten, the highest rate being comparable to that in the most sensitive animal species (hamsters) and the lowest to that in the least sensitive (rats).

Furthermore, nearly all cosmetics are for use on the skin or in the mouth and the risks of using them are very different from those encountered with a pharmacologically active drug given by mouth or injection. Some of the most aggressive chemicals used in our personal lives are fragrances. There are, at present, no ethical concerns about using long-lived cell cultures in toxicity testing. Some cells for use as test systems can be obtained by taking a blood sample from a healthy volunteer, for example, leukocytes, or from tissues obtained at operations from patients; these also pose no ethical problem, unless the tissues are obtained without patient consent.

Environmental accumulation of pesticides such as DDT High concentrations of antioxidant GSH in the liver. DNA repair differences or deficiencies Oxidative exposure Cell turnover Repair and reversibility Physiology Morphology Processing ability or metabolic activity Hormonal control Accumulation Protection mechanisms Source: Adapted from Ref. 3. on learning ability, in the nervous system, in the blood, and in the kidney and is associated with reproductive changes and may be carcinogenic. The susceptibility of organs to the effects of chemicals is influenced by a number of factors, some of which are discussed below.

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A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition by David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,


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