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Alan S. Bellack (auth.), Alan S. Bellack (eds.)'s A Clinical Guide for the Treatment of Schizophrenia PDF

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By Alan S. Bellack (auth.), Alan S. Bellack (eds.)

ISBN-10: 1475789793

ISBN-13: 9781475789799

ISBN-10: 1475789815

ISBN-13: 9781475789812

Research at the nature and remedy of schizophrenia has passed through a revival and metamorphosis within the final decade. For a protracted whereas, the sphere were moribund, weighed down by way of an unreliable diagnostic procedure, pessi­ mism concerning the threat of recent discoveries, and a dearth of study money. a couple of components have probably coalesced to alter this situa­ tion, with the outcome that the sector is now alive with pleasure and optimism. 4 components appear to have performed vital roles within the resurgence of curiosity. First, ahead of the ebook of DSM-III in 1980 there has been no trustworthy diagnostic procedure for the sickness. prior definitions have been overly basic and obscure. for that reason, the label "schizophrenia" utilized to a truly heterogeneous staff of significantly disturhed sufferers. It was once not often transparent no matter if investigators had studied related samples, making it im­ attainable to figure out if (flew findings have been generalizahle or if mess ups to copy have been because of the unreliahility of the implications or the truth that the investigators had studied varied issues. DSM-III has no longer absolutely re­ solved this challenge, however it has allowed scientists to reliably establish a way more homogeneous team. hence, it's now attainable to combine the result of various experiences, making it more likely that we will be able to make very important advances. the second one very important issue was once the advance of latest applied sciences that promised to aid discover the character and etiology of the disorder.

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Extra info for A Clinical Guide for the Treatment of Schizophrenia

Example text

Davis, J. M. (1980). What is the best maintenance dose of neuroleptics in schizophrenia? Psychiatry Research, 3, 115-122. Bannon, M. , & Roth, R. H. (1983). Pharmacology of mesocortical dopamine neurons. Pharmacological Review, 35, 53-68. Bunney B. , & Aghajanian, G. (1974). In E. Usdin & S. H. ), Frontiers in catecholamine research. Oxford: Pergammon Press. Burke, R. , Marsden, C. , Lang, A. , & I1son, J. (1982). Tardive dystonia: Late-onset and persistent dystonia caused by antipsychotic drugs.

Failure to respond to an adequate trial of different classes of neuroleptics would be considered to constitute a nonresponsive condition. The combination of different neuroleptics simultaneously is rarely indicated. There are no therapeutic advantages to these combinations, while the likelihood of negative reactions is increased. For example, the risk of neuroleptic malignant syndrome is reported to be greater when a combination of neuroleptic agents is used (although this might be explained on the basis of a 34 PHILIP T.

For example, akathisia is often mistaken for agitation. Thus, to find a dose-response relationship, fixed-dose studies, in which all patients regardless of response get the same regimen of medication, are required. The presence of spontaneous responders also makes it difficult to find an association between plasma levels and clinical response. It is not surprising that it took many years from the clinical discovery of the effectiveness of neuroleptics to studies that clearly documented the diagnostic groups that responsded and the nature of the response (NIMH-PSC Collaborative Study, 1964).

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A Clinical Guide for the Treatment of Schizophrenia by Alan S. Bellack (auth.), Alan S. Bellack (eds.)


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